| HPO |
HP:0500086 |
Optic nerve gray crescent |
"Having a characteristic appearance of a slate gray area of pigmentation within the disc margins that commonly appears along the inferotemporal or temporal neuroretinal rim areas." [PMID:24862768] |
This type of disc rim pigmentation can create the impression of neuroretinal rim thinning, and thus lead to the misdiagnosis of glaucoma or "glaucoma suspect" with attendant implications for overtreatment or unnecessary close monitoring of such patients. {xref="PMID:24862768"} |
HP:0012511 |
| HPO |
HP:0500087 |
Peripapillary atrophy |
"Thinning in the layers of the retina and retinal pigment epithelium around the optic nerve." [PMID:20920826] |
— |
HP:0012512 |
| HPO |
HP:0500088 |
Foveal depigmentation |
"Loss of pigment in the fovea centralis." [PMID:24023426] |
— |
HP:0012643 |
| HPO |
HP:0500089 |
Optic nerve sheath meningioma |
"A benign tumour of meningothelial cells of the meninges that usually occurs in middle age. It is typically unilateral and there is an association with neurofibromatosis type 2." [ISBN-13:978-0199552641] |
— |
HP:0002858 |
| HPO |
HP:0500090 |
Periocular capillary hemangioma |
"A capillary hemangioma surrounding the eyeball but within the orbit." [PMID:20616917] |
— |
HP:0005306 |
| HPO |
HP:0500091 |
Lymphangioma of the orbit |
"A hamartoma of lymph vessels that usually presents in childhood. It tends to increase in size with head-down posture and with the Valsalva manoeuvre. Superficial lesions are visible as transilluminable cystic spaces of the lid or conjunctiva that may also contain blood. Deep lesions may cause gradual proptosis or present acutely with orbital pain and reduced vision due to haemorrhage." [ISBN-13:978-0199679980] |
— |
HP:0030670, HP:0100764 |
| HPO |
HP:0500092 |
Orbital rhabdomyosarcoma |
"A mesenchymal tumour that is considered to be the commonest primary orbital malignancy in children. Histologically, it may be differentiated into embryonal, alveolar, and pleomorphic types. It is usually intraconal or within the superior orbit." [] |
— |
HP:0002859 |
| HPO |
HP:0500093 |
Food allergy |
"Primary food allergies primarily occur as a result (most likely) of gastrointestinal sensitization to predominantly stable food allergens (glycoproteins). A secondary food allergy develops after primary sensitization to airborne allergens (e. g., pollen allergens) with subsequent reactions (due to cross-reactivity) to structurally related often labile allergens in (plant) foods." [PMID:27069254, PMID:27069841] |
— |
HP:0012393 |
| HPO |
HP:0500094 |
Latex allergy |
"Latex allergy is an IgE-mediated immediate hypersensitivity response to natural rubber latex (NRL) protein with a variety of clinical signs ranging from contact urticaria, angioedema, asthma, and anaphylaxis." [PMID:15327474] |
— |
HP:0012393 |
| HPO |
HP:0500095 |
Food-induced anaphylaxis |
"Food-induced anaphylaxis is a severe, potentially fatal, systemic allergic reaction that occurs suddenly after contact with an allergy-causing food." [PMID:16461139] |
— |
HP:0100845 |
| HPO |
HP:0500096 |
Venom-induced anaphylaxis |
"A form of anaphylaxis that is triggered by exposure to venom." [PMID:21458655] |
— |
HP:0100845 |
| HPO |
HP:0500097 |
Stool xenobiotic |
"Presence of xenobiotic in stool." [] |
— |
HP:0031838 |
| HPO |
HP:0500098 |
Meconium xenobiotic |
"Presence of a xenobiotic in meconium." [] |
— |
HP:0500097 |
| HPO |
HP:0500099 |
Hair xenobiotic |
"Presence of xenobiotic in hair." [] |
— |
HP:0031838 |
| HPO |
HP:0500100 |
Plasma/serum xenobiotic |
"Presence of a xenobiotic in plasma and/or serum." [] |
— |
HP:0410172 |
| HPO |
HP:0500101 |
Gastric fluid xenobiotic |
"Presence of a xenobiotic in gastric fluid." [] |
— |
HP:0031838 |
| HPO |
HP:0500104 |
Decreased diastolic blood pressure |
"Abnormal decrease in diastolic blood pressure." [PMID:21947466] |
— |
HP:0002615 |
| HPO |
HP:0500105 |
Decreased systolic blood pressure |
"Abnormal decrease in systolic blood pressure." [PMID:21947466] |
— |
HP:0002615 |
| HPO |
HP:0500106 |
Isolated systolic hypertension |
"Elevated systolic blood pressure without an elevated blood pressure." [PMID:21947466] |
Isolated systolic hypertension or an elevated systolic blood pressure without an elevated diastolic blood pressure is a known risk factor for incident heart failure in older adults. {xref="PMID:21947466"} |
HP:0004421 |
| HPO |
HP:0500107 |
Isolated diastolic hypotension |
"A decrease in diastolic blood pressure (<60 mmHg) without a decrease in systolic blood pressure (> or = to 100 mmHg)." [PMID:21947466] |
Isolated diastolic hypotension is a risk factor for incident heart failure. {xref="PMID:21947466"} |
HP:0500104 |
| HPO |
HP:0500108 |
Positive urine cocaine test |
"Detection of cocaine or its major metabolite, benzoylecgonine, in urine." [] |
Cocaine is an illicit stimulant that has a high potential for abuse and addiction. |
HP:0031840 |
| HPO |
HP:0500109 |
Positive urine barbiturate test |
"Detection of barbiturate metabolites such as Phenobarbital in urine." [ORCID:0000-0001-7941-2961] |
Barbiturates are central nervous depressants. They can reduce heart rate, breathing, and blood pressure. {xref="PMID:26339207"} |
HP:0031840 |
| HPO |
HP:0500110 |
Positive urine cannabinoid test |
"Detection of delta-9-tetrahydrocannabinol (THC) or other cannabinoid metabolites in urine." [] |
Cannabis (marijuana, hashish) is the most widely used illegal drug in the world. The primary psychoactive component in cannabis is delta9-tetrahydrocannabinol (THC), which is rapidly metabolized to equipotent 11-hydroxy-THC (11-OH-THC) and non-psychoactive 11-nor-9-carboxy- delta9-tetrahydrocannabinol (THCCOOH). {xref="PMID:21134021"} |
HP:0031840 |
| HPO |
HP:0500111 |
Positive urine benzodiazepines test |
"Detection of benzodiazepine metabolites, primarily nordiazepam, oxazepam, and temazepam, in urine." [] |
— |
HP:0031840 |
| HPO |
HP:0500112 |
Positive urine amphetamine test |
"Detection of amphetamine or its metabolites in urine." [] |
— |
HP:0031840 |