| HPO |
HP:0001670 |
Asymmetric septal hypertrophy |
"Hypertrophic cardiomyopathy with an asymmetrical pattern of hypertrophy, with a predilection for the interventricular septum and myocyte disarray." [HPO:probinson, PMID:17916581] |
— |
HP:0001639 |
| HPO |
HP:0001671 |
Abnormal cardiac septum morphology |
"An anomaly of the intra-atrial or intraventricular septum." [HPO:probinson] |
— |
HP:0001627 |
| HPO |
HP:0001673 |
obsolete Tachycardia (with pheochromocytoma) |
— |
— |
— |
| HPO |
HP:0001674 |
Complete atrioventricular canal defect |
"A congenital heart defect characterized by a specific combination of heart defects with a common atrioventricular valve, primum atrial septal defect and inlet ventricular septal defect." [DDD:dbrown, HPO:probinson, PMID:16722604] |
The complete form of AVC shows an ostium primum atrial septal defect, a common atrioventricular valve and a variable deficiency of the interventricular septum inlet. CAVC can be classified into types A, B or C according to the morphology of the common atrioventricular valve. |
HP:0006695 |
| HPO |
HP:0001675 |
obsolete Rhythm disturbances associated with pheochromocytoma |
— |
— |
— |
| HPO |
HP:0001676 |
obsolete Palpitations (with pheochromocytoma) |
— |
— |
— |
| HPO |
HP:0001677 |
Coronary artery atherosclerosis |
"Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries, which increases the risk of myocardial ischemia." [HPO:probinson] |
Coronary artery disease, also called atherosclerotic heart disease, is the result of atheromatous plaques within the coronary arteries leading to myocardial ischemia and infarction. |
HP:0002621, HP:0006704, HP:0100545 |
| HPO |
HP:0001678 |
Atrioventricular block |
"Delayed or lack of conduction of atrial depolarizations through the atrioventricular node to the ventricles." [HPO:probinson] |
— |
HP:0005150, HP:0012722 |
| HPO |
HP:0001679 |
Abnormal aortic morphology |
"An abnormality of the aorta." [HPO:probinson, PMID:24910511] |
— |
HP:0011004, HP:0030962 |
| HPO |
HP:0001680 |
Coarctation of aorta |
"Coarctation of the aorta is a narrowing or constriction of a segment of the aorta." [HPO:probinson, PMID:23909637] |
Coarctation refers to a narrowing of the lumen of a vessel producing an obstruction to flow. Coarctation can occur in any region of the aorta. Coarctation of the aorta is often a discrete obstruction commonly located in the descending thoracic aorta. More specifically, it is usually located in the juxtaductal position immediately distal to the left-subclavian artery in a left-sided arch. The hallmark clinical finding in coarctation of the aorta is hypertension proximal to the lesion, with diminished blood pressure distal to the obstruction. Consequently, clinical diagnosis can be made by the presence of diminished lower extremity pulses, differences in timing between upper extremity central pulses (often brachial) and lower extremity central pulses (often femoral), or the presence of a supine arm-leg blood pressure gradient. |
HP:0001679 |
| HPO |
HP:0001681 |
Angina pectoris |
"Paroxysmal chest pain that occurs with exertion or stress and is related to myocardial ischemia." [HPO:probinson] |
— |
HP:0011025 |
| HPO |
HP:0001682 |
Subvalvular aortic stenosis |
"A fixed form of obstruction to blood flow across the left-ventricular outflow tract related to stenosis (narrowing) below the level of the aortic valve." [HPO:probinson] |
Narrowing of the left ventricle of the heart just below the aortic valve through which blood must pass on its way up into the aorta. |
HP:0011103 |
| HPO |
HP:0001683 |
Ectopia cordis |
"Congenital malformation of the ventral wall with partial or total evisceration of the heart outside the thoracic cavity and through the defect in the ventral wall." [DDD:dbrown] |
See Moss and Adams 'Heart Disease in Infants, Children and Adolescents' p1168. Ectopia cordis has a very poor prognosis. Ectopia cordis is generally divided into five types: cervical, cervicothoracic, thoracic, abdominal, and thoracicoabdominal. Ectopia cordis is rare (5-8 per million live births), but the two most common forms are thoracic (59%) and thoracicoabdominal (38%). |
HP:0004307 |
| HPO |
HP:0001684 |
Secundum atrial septal defect |
"A kind of atrial septum defect arising from an enlarged foramen ovale, inadequate growth of the septum secundum, or excessive absorption of the septum primum." [DDD:dbrown, HPO:probinson] |
— |
HP:0001631 |
| HPO |
HP:0001685 |
Myocardial fibrosis |
"Myocardial fibrosis is characterized by dysregulated collagen turnover (increased synthesis predominates over unchanged or decreased degradation) and excessive diffuse collagen accumulation in the interstitial and perivascular spaces as well as by phenotypically transformed fibroblasts, termed myofibroblasts." [PMID:28157267] |
Myocardial fibrosis disrupts the myocardial architecture, contributes to myocardial disarray, and determines mechanical, electrical, and vasomotor dysfunction, thus promoting the progression of cardiac diseases to heart failure. |
HP:0001637 |
| HPO |
HP:0001686 |
Loss of voice |
— |
— |
HP:0001608 |
| HPO |
HP:0001688 |
Sinus bradycardia |
"Bradycardia related to a mean resting sinus rate of less than 50 beats per minute." [HPO:probinson] |
— |
HP:0001662, HP:0011702 |
| HPO |
HP:0001691 |
Muscular subvalvular aortic stenosis |
"A type of subvalvular aortic stenosis resulting from thickening of the musculature of the interventricular septum, which results in obstruction to blood flow through the left-ventricular outflow tract." [HPO:probinson] |
— |
HP:0001682 |
| HPO |
HP:0001692 |
Atrial arrhythmia |
"A type of supraventricular tachycardia in which the atria are the principal site of electrophysiologic disturbance." [DDD:dbrown] |
— |
HP:0005115 |
| HPO |
HP:0001693 |
Cardiac shunt |
"Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system." [HPO:probinson] |
— |
HP:0011028 |
| HPO |
HP:0001694 |
Right-to-left shunt |
"Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from the right side of the heart to the left." [HPO:mhaendel] |
— |
HP:0001693 |
| HPO |
HP:0001695 |
Cardiac arrest |
"An abrupt loss of heart function." [] |
— |
HP:0011675 |
| HPO |
HP:0001696 |
Situs inversus totalis |
"A left-right reversal (or \"mirror reflection\") of the anatomical location of the major thoracic and abdominal organs." [DDD:dbrown, HPO:probinson] |
— |
HP:0001651, HP:0011534 |
| HPO |
HP:0001697 |
Abnormal pericardium morphology |
"An abnormality of the pericardium, i.e., of the fluid filled sac that surrounds the heart and the proximal ends of the aorta, vena cava, and the pulmonary artery." [HPO:probinson] |
— |
HP:0001627 |
| HPO |
HP:0001698 |
Pericardial effusion |
"Accumulation of fluid within the pericardium." [HPO:probinson] |
— |
HP:0001697 |