| HPO |
HP:0011896 |
Subconjunctival hemorrhage |
"Bleeding beneath the mucous membrane that lines the inner surface of the eyelid." [DDD:akelly] |
— |
HP:0011885 |
| HPO |
HP:0011897 |
Neutrophilia |
"Increased number of neutrophils circulating in blood." [DDD:akelly] |
— |
HP:0011991 |
| HPO |
HP:0011898 |
Abnormality of circulating fibrinogen |
"An abnormality of the level of activity of circulating fibrinogen." [DDD:akelly] |
Fibrinogen is an essential hemostatic factor that is converted to fibrin (a final product of the hemostatic pathway) by activated thrombin. |
HP:0010990 |
| HPO |
HP:0011899 |
Hyperfibrinogenemia |
"Increased concentration of fibrinogen in the blood." [DDD:akelly] |
— |
HP:0011898 |
| HPO |
HP:0011900 |
Hypofibrinogenemia |
"Decreased concentration of fibrinogen in the blood." [HPO:probinson] |
— |
HP:0011898 |
| HPO |
HP:0011901 |
Dysfibrinogenemia |
"Qualitatively abnormal fibrinogen." [DDD:akelly] |
— |
HP:0011898 |
| HPO |
HP:0011902 |
Abnormal hemoglobin |
"Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes." [HPO:probinson] |
— |
HP:0001877 |
| HPO |
HP:0011903 |
HbH hemoglobin |
"Hemoglobin H (HbH) contains four beta-globin chains. It is normally not present at all in blood, but may make up about 1-40 percent of all hemoglobin in HbH disease, a subform of alpha thalassemia." [HPO:probinson, PMID:21345100] |
— |
HP:0011902 |
| HPO |
HP:0011904 |
Persistence of hemoglobin F |
"Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent." [HPO:probinson] |
— |
HP:0011902 |
| HPO |
HP:0011905 |
Reduced hemoglobin A |
"Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia." [HPO:probinson] |
— |
HP:0011902 |
| HPO |
HP:0011906 |
Reduced beta/alpha synthesis ratio |
"A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia." [HPO:probinson, PMID:1060068] |
— |
HP:0005560 |
| HPO |
HP:0011907 |
Reduced alpha/beta synthesis ratio |
"A reduction in the ratio of production of alpha globin to that of beta globin. This is the major abnormality in the various forms of alpha thalassemia." [HPO:probinson] |
— |
HP:0005560 |
| HPO |
HP:0011908 |
Unilateral radial aplasia |
"Missing radius bone on one side only associated with congenital failure of development." [HPO:probinson] |
— |
HP:0003974 |
| HPO |
HP:0011909 |
Flattened metacarpal heads |
"Abnormally flat shape of the heads of the metacarpal bones." [HPO:probinson] |
The metacarpal heads articulate with the proximal phalanges of the fingers. |
HP:0005916 |
| HPO |
HP:0011910 |
Shortening of all phalanges of fingers |
"Abnormal reduction in length affecting all phalanges." [HPO:probinson] |
— |
HP:0009803 |
| HPO |
HP:0011911 |
Abnormality of metacarpophalangeal joint |
"An anomaly of a metacarpophalangeal joint." [HPO:probinson] |
— |
HP:0001163 |
| HPO |
HP:0011912 |
Abnormality of the glenoid fossa |
"An anomaly of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus." [HPO:probinson] |
— |
HP:0000782, HP:0003043 |
| HPO |
HP:0011913 |
Lumbar hypertrichosis |
"Excessive, increased hair growth located in the lumbar region." [HPO:probinson] |
— |
HP:0000998 |
| HPO |
HP:0011914 |
Thoracic hypertrichosis |
"Excessive, increased hair growth located in the thoracic region." [HPO:probinson] |
— |
HP:0000998 |
| HPO |
HP:0011915 |
Cardiovascular calcification |
"Abnormal calcification in the cardiovascular system." [HPO:probinson] |
— |
HP:0010766, HP:0030680 |
| HPO |
HP:0011916 |
Toe extensor amyotrophy |
"Atrophy of the extensor digitorum longus muscles, which mediate extension of the toes." [HPO:probinson] |
— |
HP:0001436 |
| HPO |
HP:0011917 |
Short 5th toe |
"Underdevelopment (hypoplasia) of the fifth toe." [HPO:probinson] |
— |
HP:0001831 |
| HPO |
HP:0011918 |
Clinodactyly of the 4th toe |
"Bending or curvature of a fourth toe in the tibial direction (i.e., towards the big toe)." [HPO:probinson] |
— |
HP:0001863, HP:0010338 |
| HPO |
HP:0011919 |
Pleural empyema |
"Accumulation of pus in the pleural cavity." [HPO:probinson] |
— |
HP:0002202 |
| HPO |
HP:0011920 |
Transudative pleural effusion |
"A type of pleural effusion with a transudate (extravascular fluid with low protein content and a low specific gravity). Pleural effusions can be classified as transudates or exudates based on Light's criteria, which classify an effusion as exudate if one or more of the following are present: (1) the ratio of pleural fluid protein to serum protein is greater than 0.5, (2) the ratio of pleural fluid lactate dehydrogenase (LDH) to serum LDH is greater than 0.6, or (3) the pleural fluid LDH level is greater than two thirds of the upper limit of normal for serum LDH." [DDD:tkuijpers, HPO:probinson, PMID:16623208] |
Transudates result from imbalances in hydrostatic and oncotic forces and are caused by a limited number of recognized clinical conditions such as heart failure and cirrhosis. Less common causes include nephrotic syndrome, atelectasis, peritoneal dialysis, constrictive pericarditis, superior vena caval obstruction, and urinothorax. |
HP:0002202 |