| HPO |
HP:0011871 |
Impaired ristocetin-induced platelet aggregation |
"Abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin." [DDD:wouwehand] |
— |
HP:0003540, HP:0012146 |
| HPO |
HP:0011872 |
Impaired thrombin-induced platelet aggregation |
"Abnormal response to thrombin or thrombin mimetics as manifested by reduced or lacking aggregation of platelets upon addition of thrombin (or thrombin mimetics)." [DDD:wouwehand] |
— |
HP:0003540 |
| HPO |
HP:0011873 |
Abnormal platelet count |
"Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood." [DDD:kfreson] |
— |
HP:0001872 |
| HPO |
HP:0011874 |
Heparin-induced thrombocytopenia |
"Low platelet count following administration of unfractionated or (less commonly) low-molecular weight heparin." [HPO:probinson, PMID:16928996] |
A delay of 5-10 days following administration of heparin is common in patients with no previous (or remote) exposure to heparin, but the drop in platelet count may be precipitous in patients with recent exposure. Heparin-induced thrombocytopenia is caused by antibodies against platelet factor 4. |
HP:0001873 |
| HPO |
HP:0011875 |
Abnormal platelet morphology |
"An anomaly in platelet form, ultrastructure, or intracellular organelles." [DDD:kfreson] |
— |
HP:0001872 |
| HPO |
HP:0011876 |
Abnormal platelet volume |
"Anomalous size of platelets. Most normal sized platelets are 1.5 to 3 micrometers in diameter. Large platelets are 4 to 7 micrometers. Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers." [HPO:probinson] |
— |
HP:0001872 |
| HPO |
HP:0011877 |
Increased mean platelet volume |
"Average platelet volume above the upper limit of the normal reference interval." [DDD:wouwehand] |
Mean platelet volume (MPV) is a measure of the average size of platelets, with a typical reference range of 7.5 to 11.5 femtoliters (fL). |
HP:0011876 |
| HPO |
HP:0011878 |
Abnormal platelet membrane protein expression |
"Presence of reduced amount of a membrane protein on the cell membrane of platelets. This feature is typically measured by flow cytometry." [DDD:wouwehand] |
— |
HP:0011869 |
| HPO |
HP:0011879 |
Decreased platelet glycoprotein Ib-IX-V |
"Decreased cell membrane concentration of the glycoprotein complex Ib-IX-V." [DDD:wouwehand, PMID:10605725] |
The glycoprotein Ib-IX-V complex forms a specific platelet membrane adhesion receptor, which binds the adhesive glycoprotein, von Willebrand factor (vWF), in the vessel wall or plasma. |
HP:0011878 |
| HPO |
HP:0011880 |
Acute disseminated intravascular coagulation |
"An acute form of disseminated intravascular coagulation. Acute DIC can occur following sudden exposure of blood to procoagulants, with the compensatory hemostatic mechanisms becoming overwhelmed." [HPO:probinson] |
— |
HP:0005521 |
| HPO |
HP:0011881 |
Decreased platelet glycoprotein VI |
"Decreased cell membrane concentration of glycoprotein VI." [DDD:wouwehand] |
The glycoprotein VI is a glycoprotein receptor for collagen. |
HP:0011878 |
| HPO |
HP:0011882 |
Decreased platelet P2Y12 receptor |
"Decreased cell membrane concentration of P2Y12 receptor." [DDD:wouwehand, PMID:14755328] |
The P2Y12 receptor is activated by ADP and plays a central role in platelet activation. |
HP:0011878 |
| HPO |
HP:0011883 |
Abnormal platelet granules |
"An anomaly of alpha or dense granules or platelet lysosomes." [DDD:wouwehand, PMID:18041654] |
Platelets contain two classes of granule: the alpha granules and the dense granules. During platelet activation, the contents of the granules are discharged into the lumen of the open canalicular system, from which they are then released to the extracellular space. |
HP:0011875 |
| HPO |
HP:0011884 |
Abnormal umbilical stump bleeding |
"Abnormal bleeding of the umbilical stump following separation of the cord at approximately 7-10 days after birth." [DDD:akelly] |
— |
HP:0001892 |
| HPO |
HP:0011885 |
Hemorrhage of the eye |
"Bleeding from vessels of the various tissues of the eye." [DDD:akelly] |
— |
HP:0011029, HP:0012373 |
| HPO |
HP:0011886 |
Hyphema |
"Bleeding in the anterior chamber of the eye." [HPO:probinson] |
— |
HP:0011885 |
| HPO |
HP:0011887 |
Choroid hemorrhage |
"Hemorrhage from the vessels of the choroid." [HPO:probinson] |
— |
HP:0011885 |
| HPO |
HP:0011888 |
Bleeding requiring red cell transfusion |
"Bleeding sufficiently severe as to require red cell transfusion (WHO Grade 3 or 4)." [DDD:akelly] |
— |
HP:0001892 |
| HPO |
HP:0011889 |
Bleeding with minor or no trauma |
"Significant bleeding or hemorrhage without significant precipitating factor." [DDD:kfreson] |
— |
HP:0001892 |
| HPO |
HP:0011890 |
Prolonged bleeding following procedure |
"Prolonged or protracted bleeding following an invasive procedure or intervention." [DDD:akelly] |
— |
HP:0001892 |
| HPO |
HP:0011891 |
Post-partum hemorrhage |
"Significant maternal haemorrhage/blood loss following deilvery of a child." [DDD:akelly] |
— |
HP:0011890 |
| HPO |
HP:0011892 |
Low levels of vitamin K |
"A reduced concentration of vitamin K." [] |
— |
HP:0100831 |
| HPO |
HP:0011893 |
Abnormal leukocyte count |
"Number of leukocytes per volume of blood beyond normal limits." [HPO:probinson] |
— |
HP:0001881 |
| HPO |
HP:0011894 |
Impaired thromboxane A2 agonist-induced platelet aggregation |
"Abnormal response to thromboxane as manifested by reduced or lacking aggregation of platelets upon addition of thromboxane A2 receptor agonists." [DDD:wouwehand] |
— |
HP:0003540 |
| HPO |
HP:0011895 |
Anemia due to reduced life span of red cells |
"A type of anemia related to a reduction in the average life span of red blood cells in the peripheral circulation, which is normally around 120 days." [DDD:akelly] |
— |
HP:0001903 |