| HPO |
HP:0002287 |
Progressive alopecia |
"Progressive loss of hair." [HPO:probinson] |
— |
HP:0001596 |
| HPO |
HP:0002289 |
Alopecia universalis |
"Loss of all hair on the entire body." [HPO:probinson] |
— |
HP:0001596 |
| HPO |
HP:0002290 |
Poliosis |
"Circumscribed depigmentation of the hair of the head or the eyelashes." [HPO:probinson] |
— |
HP:0011365 |
| HPO |
HP:0002292 |
Frontal balding |
"Absence of hair in the anterior midline and/or parietal areas." [PMID:19125436] |
— |
HP:0011360 |
| HPO |
HP:0002293 |
Alopecia of scalp |
— |
— |
HP:0001596, HP:0100037 |
| HPO |
HP:0002296 |
Progressive hypotrichosis |
"Progressively reduced or lacking hair growth." [HPO:curators] |
— |
HP:0008070 |
| HPO |
HP:0002297 |
Red hair |
— |
— |
HP:0009887 |
| HPO |
HP:0002298 |
Absent hair |
— |
— |
HP:0011362 |
| HPO |
HP:0002299 |
Brittle hair |
"Fragile, easily breakable hair, i.e., with reduced tensile strength." [DDD:cmoss] |
Brittle is used to describe hair which is very short because of an abnormality is in the structure of the shaft. Microscopically the ends appear fractured. Affected patients may report bits of hair on the collar or pillow. Brittle hair can be distinguished from hypotrichosis due to slow or deficient growth (e.g., due to hypotrichosis simplex) and hypotrichosis due to the hair being fine and soft where the hair just wears out too quickly (e.g., due to ectodermal dysplasia). |
HP:0010719 |
| HPO |
HP:0002300 |
Mutism |
— |
— |
HP:0000708, HP:0002167 |
| HPO |
HP:0002301 |
Hemiplegia |
"Paralysis (complete loss of muscle function) in the arm, leg, and in some cases the face on one side of the body." [HPO:curators] |
— |
HP:0004374 |
| HPO |
HP:0002304 |
Akinesia |
"Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily." [HPO:probinson] |
Akinesia is a typical extrapyramidal abnormality. |
HP:0002374 |
| HPO |
HP:0002305 |
Athetosis |
"A slow, continuous, involuntary writhing movement that prevents maintenance of a stable posture. Athetosis involves continuous smooth movements that appear random and are not composed of recognizable sub-movements or movement fragments. In contrast to chorea, in athetosis, the same regions of the body are repeatedly involved. Athetosis may worsen with attempts at movement of posture, but athetosis can also occur at rest." [HPO:probinson, PMID:20589866] |
Athetosis derives from the Greek word for 'changeable' or 'unfixed'. |
HP:0004305 |
| HPO |
HP:0002307 |
Drooling |
"Habitual flow of saliva out of the mouth." [HPO:probinson, PMID:15202698] |
— |
HP:0000708, HP:0003781 |
| HPO |
HP:0002308 |
Arnold-Chiari malformation |
"Arnold-Chiari malformation consists of a downward displacement of the cerebellar tonsils and the medulla through the foramen magnum, sometimes causing hydrocephalus as a result of obstruction of CSF outflow." [HPO:curators] |
— |
HP:0002438 |
| HPO |
HP:0002310 |
Orofacial dyskinesia |
— |
— |
HP:0100660 |
| HPO |
HP:0002311 |
Incoordination |
— |
— |
HP:0011443 |
| HPO |
HP:0002312 |
Clumsiness |
"Lack of physical coordination resulting in an abnormal tendency to drop items or bump into objects." [HPO:probinson] |
— |
HP:0002311 |
| HPO |
HP:0002313 |
Spastic paraparesis |
— |
— |
HP:0002061, HP:0002385 |
| HPO |
HP:0002314 |
Degeneration of the lateral corticospinal tracts |
"Deterioration of the tissues of the lateral corticospinal tracts." [HPO:probinson] |
— |
HP:0007372 |
| HPO |
HP:0002315 |
Headache |
"Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve." [HPO:probinson, PMID:15304572] |
Headache is one of the most common types of recurrent pain as well as one of the most frequent symptoms in neurology. In addition to occasional headaches, there are well-defined headache disorders that vary in incidence, prevalence and duration and can be divided into two broad categories. In secondary headache disorders, headaches are attributed to another condition, such as brain tumour or head injury; for the primary disorders the headache is not due to another condition. |
HP:0012638 |
| HPO |
HP:0002317 |
Unsteady gait |
— |
— |
HP:0001288 |
| HPO |
HP:0002318 |
Cervical myelopathy |
— |
— |
HP:0002196 |
| HPO |
HP:0002321 |
Vertigo |
"An abnormal sensation of spinning while the body is actually stationary." [HPO:probinson] |
— |
HP:0001751 |
| HPO |
HP:0002322 |
Resting tremor |
"A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse." [HPO:probinson, PMID:22675666] |
Resting tremor vanishes with active movement, but typically reappears after a few seconds when the arms are held outstretched (reemergent tremor). In Parkinson disease, rest tremor frequency is usually in the low to mid-range (3-6 Hz), and the amplitude is quite variable, from less than 1 cm to over 10 cm in width. |
HP:0001337 |