| HPO |
HP:0002087 |
Abnormality of the upper respiratory tract |
"An abnormality of the upper respiratory tract." [HPO:probinson] |
— |
HP:0012252 |
| HPO |
HP:0002088 |
Abnormal lung morphology |
"Any structural anomaly of the lung." [HPO:probinson] |
— |
HP:0012252 |
| HPO |
HP:0002089 |
Pulmonary hypoplasia |
— |
— |
HP:0006703 |
| HPO |
HP:0002090 |
Pneumonia |
"Inflammation of any part of the lung parenchyma." [HPO:probinson] |
— |
HP:0011947, HP:0012649 |
| HPO |
HP:0002091 |
Restrictive ventilatory defect |
"A functional defect characterized by reduced total lung capacity (TLC) not associated with abnormalities of expiratory airflow or airway resistance. Spirometrically, a restrictive defect is defined as FEV1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) less than 80 per cent. Restrictive lung disease may be caused by alterations in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus." [NIHR:ldaugherty, PMID:28194273] |
The most commonly used term for this feature is restrictive lung disease, but we choose the term Restrictive ventilatory defect to emphasize that this term refers to a phenotypic feature rather than a disease entity. |
HP:0030878 |
| HPO |
HP:0002092 |
Pulmonary arterial hypertension |
"Pulmonary hypertension is defined mean pulmonary artery pressure of 25mmHg or more and pulmonary capillary wedge pressure of 15mmHg or less when measured by right heart catheterisation at rest and in a supine position." [HPO:probinson] |
Pulmonary hypertension can be secondary to known cardiac, pulmonary, or hepatic disease. If no cause is identifiable, the term primary pulmonary hypertension is used. |
HP:0033578 |
| HPO |
HP:0002093 |
Respiratory insufficiency |
— |
— |
HP:0002795 |
| HPO |
HP:0002094 |
Dyspnea |
"Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale." [HPO:probinson, PMID:16914301] |
— |
HP:0002793 |
| HPO |
HP:0002097 |
Emphysema |
— |
— |
HP:0002088 |
| HPO |
HP:0002098 |
Respiratory distress |
"Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea." [] |
— |
HP:0002094 |
| HPO |
HP:0002099 |
Asthma |
"Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing." [HPO:probinson] |
— |
HP:0002795, HP:0100326 |
| HPO |
HP:0002100 |
Recurrent aspiration pneumonia |
"Increased susceptibility to aspiration pneumonia, defined as pneumonia due to breathing in foreign material, as manifested by a medical history of repeated episodes of aspiration pneumonia." [HPO:probinson] |
— |
HP:0011951 |
| HPO |
HP:0002101 |
Abnormal lung lobation |
"A developmental defect in the formation of pulmonary lobes." [HPO:probinson] |
— |
HP:4000059 |
| HPO |
HP:0002102 |
Pleuritis |
"Inflammation of the pleura." [HPO:sdoelken] |
— |
HP:0002103 |
| HPO |
HP:0002103 |
Abnormal pleura morphology |
"An abnormality of the pulmonary pleura, the thin, transparent membrane which covers the lungs and lines the inside of the chest walls." [HPO:probinson] |
— |
HP:0002088 |
| HPO |
HP:0002104 |
Apnea |
"Lack of breathing with no movement of the respiratory muscles and no exchange of air in the lungs. This term refers to a disposition to have recurrent episodes of apnea rather than to a single event." [HPO:curators] |
— |
HP:0002793 |
| HPO |
HP:0002105 |
Hemoptysis |
"Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs." [HPO:probinson] |
— |
HP:0032016 |
| HPO |
HP:0002107 |
Pneumothorax |
"Accumulation of air in the pleural cavity leading to a partially or completely collapsed lung." [HPO:probinson] |
— |
HP:0002103 |
| HPO |
HP:0002108 |
Spontaneous pneumothorax |
"Pneumothorax occurring without traumatic injury to the chest or lung." [HPO:probinson] |
— |
HP:0002107 |
| HPO |
HP:0002109 |
obsolete Abnormality of the bronchi |
— |
— |
— |
| HPO |
HP:0002110 |
Bronchiectasis |
"Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways." [HPO:probinson] |
— |
HP:0025426 |
| HPO |
HP:0002111 |
obsolete Restrictive deficit on pulmonary function testing |
— |
— |
— |
| HPO |
HP:0002113 |
Pulmonary infiltrates |
— |
— |
HP:0031983 |
| HPO |
HP:0002118 |
Abnormal cerebral ventricle morphology |
"Any structural abnormality of the cerebral ventricles." [HPO:probinson] |
— |
HP:0012443 |
| HPO |
HP:0002119 |
Ventriculomegaly |
"An increase in size of the ventricular system of the brain." [HPO:probinson] |
— |
HP:0002118 |