| HPO |
HP:0025059 |
Splenic abscess |
"A circumscribed area of pus or necrotic debris in the parenchyma of the spleen." [PMID:21319348] |
Splenic abscesses generally occur in patients with neoplasia, immunodeficiency, trauma, metastatic infection, splenic infarct or diabetes. |
HP:0025408 |
| HPO |
HP:0025060 |
Multifocal splenic abscess |
"Multiple abscess lesions in the spleen." [] |
— |
HP:0025059 |
| HPO |
HP:0025061 |
Unifocal splenic abscess |
"Single (solitary) abscess in the spleen." [] |
— |
HP:0025059 |
| HPO |
HP:0025062 |
Geophagia |
"The practice of eating earth or soil-like substrates such as clay or chalk." [PMID:23816735] |
— |
HP:0011856 |
| HPO |
HP:0025063 |
Scaphoid abdomen |
"The anterior abdominal wall is sunken and presents a concave rather than a convex contour." [] |
Scaphoid abdomen can be observed in diseases such as congenital diaphragmatic hernia (since the abdominal contents can be in the thorax). |
HP:0011458 |
| HPO |
HP:0025064 |
Thalamic hemorrhage |
"Bleeding in the thalamus." [] |
Thalamic hemorrhage may be observed in individuals with hypertension. In both the acute and chronic phases of bleeding, prominent susceptibility effect, seen as hypointense blooming on sequences, is typically seen upon magnetic resonance imaging. |
HP:0010663 |
| HPO |
HP:0025065 |
Abnormal mean corpuscular volume |
"A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters." [] |
— |
HP:0001877 |
| HPO |
HP:0025066 |
Decreased mean corpuscular volume |
"A reduction from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells (usually defined as an MCV below 80 femtoliters)." [] |
— |
HP:0025065 |
| HPO |
HP:0025068 |
Incomitant strabismus |
"Strabismus in which the angle of deviation differs depending upon the direction of gaze or according to which eye is fixing, associated with: (i) defective movement of the eye, (ii) asymmetrical accommodative effort." [ORCID:0000-0003-0986-4123] |
— |
HP:0000486 |
| HPO |
HP:0025069 |
Concomitant strabismus |
"Strabismus in which the angle of deviation of the squiting eye remains the same in relation to the other eye, in all directions of gaze, and whichever eye is fixing." [] |
— |
HP:0000486 |
| HPO |
HP:0025070 |
Abnormal U wave |
"An anomaly of the U wave of the electrocardiogram (EKG). The U wave is a small (0.5 mm) deflection immediately following the T wave, usually in the same direction as the T wave. It is best seen in leads V2 and V3." [PMID:22665396] |
U waves represent prolonged repolarisation of myocardial M cells. Under normal conditions the M cells are electrically coupled to adjacent cell layers. However, in conditions that produce electrical uncoupling, these M cells have significant effects on repolarisation producing prolonged rounded ST-T waves or U waves. The finding of U wave inversion on an ECG at rest or baseline is a non-specific finding. It is significant when observed post exercise, being originally described in early 1940s. Subsequent studies in the late 1970s, demonstrated a significant correlation of U wave inversion with either left main or LAD disease. |
HP:0003115 |
| HPO |
HP:0025071 |
U wave inversion |
"Direction of the U wave opposite to the T wave (i.e., below baseline) in leads with upright T waves." [] |
Inverted U wave may be a sign of coronary artery disease, hypertension, valvular heart disease, congenital heart disease, cardiomyopathy, or hyperthyroidism. In individuals with acute chest pain, it may be a sign of myocardial ischemia. |
HP:0025070 |
| HPO |
HP:0025072 |
Prominent U wave |
"Increased amplitude of the U wave, defined as an amplitude grerater than 1-2mm or 25 percent of the height of the T wave." [] |
— |
HP:0025070 |
| HPO |
HP:0025073 |
Exercise-induced U wave inversion |
"U wave inversion that is induced by exercise stress testing." [PMID:22665396] |
— |
HP:0025071 |
| HPO |
HP:0025074 |
Abnormal QRS complex |
"An anomaly of the complex formed by the Q, R, and S waves, which occur in rapid succession on the electrocardiogram." [] |
— |
HP:0003115 |
| HPO |
HP:0025075 |
Increased QRS voltage |
"Elevation of the voltage (height) of the QRS complex. There are several criteria in use, but the most common is the Sokolov-Lyon criterion (S wave depth in V1 + tallest R wave height in V5-V6 greater than 35 mm)." [] |
— |
HP:0025076 |
| HPO |
HP:0025076 |
Abnormal QRS voltage |
"Abnormal amplitude of the QRS complex of the electrocardiogram (EKG)." [] |
— |
HP:0025074 |
| HPO |
HP:0025077 |
Decreased QRS voltage |
"Reduced amplitude (height) of the QRS complex of the electrocardiogram (EKG), defined as amplitudes of all the QRS complexes in the limb leads are less than 5 mm or amplitudes of all the QRS complexes in the precordial leads less than 10 mm." [] |
— |
HP:0025076 |
| HPO |
HP:0025078 |
Electrical alternans |
"The QRS complexes of the electrocardiogram alternate in height." [PMID:8222799] |
— |
HP:0025076 |
| HPO |
HP:0025079 |
Pancreatic abscess |
"A circumscribed area of pus or necrotic debris in the parenchyma of the pancreas." [] |
— |
HP:0012090, HP:0025615 |
| HPO |
HP:0025080 |
Orthokeratotic hyperkeratosis |
"A form of hyperkeratosis characterized by thickening of the cornified layer without retained nuclei." [] |
Hyperkeratosis is most commonly orthokeratotic. |
HP:0000962 |
| HPO |
HP:0025081 |
Darier's sign |
"A skin change elicited by briskly rubbing the skin lesion in urticaria pigmentosa (UP), whereby the area begins to itch and becomes raised and surrounded by erythema. Unlike other forms of dermatographism, Darier's sign refers to urtication that is limited to the UP involved areas and, as in this case, spares the skin unaffected by UP." [PMID:24701633] |
— |
HP:0001025 |
| HPO |
HP:0025082 |
Abnormal cutaneous elastic fiber morphology |
"Any structural anomaly of the elastic fibers of the skin. Elastic fibers are the essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils." [PMID:12082143, PMID:21738362] |
Elastic fibers help the skin return to its normal configuration after being stretched or deformed. The elastic fibers consist of two components: microfibrils and matrix elastin. The microfibrillar component amounts to only 15% of the elastic fiber, whereas the amorphous, electron-lucid elastin makes up 85% of the fiber. In light microscope sections that are routinely stained, elastic fibers are inconspicuous. With special elastic tissue stains, such as orcein or resorcin-fuchisin, or in plastic-embedded sections they are found entwined among the collagen bundles [PMID:21738362]. |
HP:0011121 |
| HPO |
HP:0025083 |
Elevated dermal desmosine content |
"An increased amount of desmosine measure in the skin. Desmosine is a cross-linking amino acid formed from lysyl residues in elastin." [PMID:2307214] |
Disorders of elastosis may show an increased content of desmosines, whereas elastolytic disorders may show a reduced content of desmosine. |
HP:0011121 |
| HPO |
HP:0025084 |
Folliculitis |
"Inflammatory cells within the wall and ostia of the hair follicle, creating a follicular-based pustule." [] |
In contrast to folliculitis, perifolliculitis refers to inflammatory cells, usually lymphocytes, within the perifollicular tissues with focal extension into the adjacent reticular dermis. Folliculitis and perifolliculitis can occur independently or incombination owing to follicular disruption and irritation. |
HP:0011123 |