Db	Link	Name	Definition	Comment	Is a
HPO	HP:0020090	Post-vaccination polio	"Infection with live attenuated polio vaccine following vaccination. This is an extreemely rare event that may indicate immunocompromise." [PMID:25285130]	—	HP:0020085
HPO	HP:0020091	Post-vaccination rotavirus infection	"Infection with live attenuated rotavirus vaccine following vaccination." [PMID:21477676]	—	HP:0020085
HPO	HP:0020093	Recurrent deep organ abscess formation	"Repeated episodes of the formation of abscesses in organs. An abscess is a circumscribed area of pus or necrotic debris in the parenchyma or an organ." []	—	HP:0032169
HPO	HP:0020095	Prolonged need of intravenous antibiotic therapy	"Clinical assessment of a requirement to treat with intravenous antibiotics over an unusually prolonged period of time." []	—	HP:0032169
HPO	HP:0020096	Recurrent streptococcal infections	"Increased susceptibility to streptococcal infections, as manifested by recurrent episodes of streptococcal infections." []	—	HP:0002718
HPO	HP:0020097	Infection due to encapsulated bacteria	"An infection by an encapsulated bacterial agent. Isolates which cause invasive disease are usually surrounded by a polysaccharide capsule, which is a major virulence factor and the key antigen in protective protein-polysaccharide conjugate vaccines." [PMID:30515161]	Encapsulated bacteria have been responsible for the majority of bacteremia and meningitis in children for many decades. In children aged over 3 months, Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus), and Haemophilus influenzae have been the predominant pathogens, with H. influenzae being a less significant problem since the introduction of vaccines against type b organisms. Disease is most common in young children less than 5 years of age and older adults aged over 65 years. In neonates and young infants, Group B Streptococcus (GBS) is the major cause of bacteremia and meningitis. These organisms have the shared characteristic of being surrounded by a polysaccharide capsule, which is a key virulence factor because it helps the bacteria evade complement deposition and subsequent phagocytosis and killing. These polysaccharides have also been the basis for successful vaccines against all except GBS, because immune responses against the polysaccharide capsule are the primary mechanism of protection for the human host. Each species can be encapsulated by polysaccharides of different biochemical compositions, which has been used for categorization into capsular groups or serotypes.	HP:0032260
HPO	HP:0020098	Herpes encephalitis	"Infection of the brain parenchyma with herpes simplex virus, resulting in inflammation of the brain parenchyma with neurologic dysfunction." [PMID:27106239]	Herpes encephalitis may occur in mmunocompromised patients, but HSV-1 is consistently the single most common cause of sporadic encephalitis worldwide.	HP:0033993
HPO	HP:0020099	Severe norovirus infection	"An unusually severe course of infection with Human norovirus, previously known as Norwalk virus. Norovirus, an RNA virus of the family Caliciviridae, is a human enteric pathogen. Norovirus infection-associated illness may also be more prolonged and severe in immunocompromised individuals and may be associated with remarkably persistent viral excretion in some of these individuals." [PMID:25567225]	—	HP:0032169
HPO	HP:0020100	Unusual fungal infection	"An unusual fungal infection that is regarded as a sign of a pathological susceptibility to infection by a fungal agent." []	—	HP:0032101
HPO	HP:0020101	Invasive fungal infection	"Fungal infection characterized by invasion of host tissues." [PMID:24718393]	Invasive fungal infections are a significant health problem in immunocompromised patients. Major risk factors for IFI include neutropenia less than 500 neutrophils/ml for more than 10 days, haematological malignancies, bone marrow transplantation, prolonged (over 4 wk) treatment with corticosteroids; prolonged (over 7 days) stays in intensive care, chemotherapy, HIV infection, invasive medical procedures, and the newer immune suppressive agents.	HP:0020100
HPO	HP:0020102	Pneumocystis jirovecii pneumonia	"An opportunistic disease caused by invasion of unicellular fungus Pneumocystis jirovecii. Transmission of P. jirovecii cysts takes place through the airborne route, and usually, its presence in lungs is asymptomatic. However, people with impaired immunity, especially those with CD4+ T cell count below 200/microliter, are still at risk of the development of Pneumocystis pneumonia due to P. jirovecii invasion. Symptoms induced by this disease are not specific: progressive dyspnoea, non-productive cough, low-grade fever, arterial partial pressure of oxygen below 65 mmHg, and chest radiographs demonstrating bilateral, interstitial shadowing." [PMID:26281787]	Pneumocystis, initially considered to be a protozoan, later has been assigned to the kingdom of fungi.	HP:0032255
HPO	HP:0020103	Invasive pulmonary aspergillosis	"Infection of the lungs with aspergillus. In the respiratory mucosa, the spores may germinate into hyphae, which in turn can invade the mucosa leading to invasive pulmonary aspergillosis." [PMID:25656673]	Invasive pulmonary aspergillosis usually occurs in severely immunocompromised patients. Classic at-risk patients are those with prolonged neutropenia, either due to chemotherapy or immunosuppressive therapy, post hematopoietic stem cell transplant (SCT), or solid organ transplant.	HP:0020101
HPO	HP:0020104	Unusual protozoan infection	"An unusual protozoan infection that is regarded as a sign of a pathological susceptibility to infection by a protozoal agent." []	—	HP:0032101
HPO	HP:0020105	Severe toxoplasmosis	"Toxoplasmosis is a widespread parasitic infection that is frequently asymptomatic in immunocompetent patients. However, this obligate intracellular protozoan parasite can evade the immune system and persist for the life of its host in cyst form, predominantly in the brain, retina, and muscles. Reactivation of latent cysts may occur when the immune system fails to maintain cytokine pressure, which mainly relies on gamma interferon (IFN-gamma). Toxoplasmosis is a life-threatening infection in immunocompromised patients (ICPs)." [PMID:25762774]	—	HP:0020104
HPO	HP:0020106	Severe giardiasis	"An unusually severe infection due to Giardia lamblia, also called Giardia duodenalis or Giardia intestinalis, which is a protozoan parasite of the small intestine that causes extensive morbidity worldwide." [PMID:11148005, PMID:17042927]	Several reports of giardiasis in immunocompromised patients exist.	HP:0020104
HPO	HP:0020107	Unusual helminthic infection	"An unusual helminthic infection that is regarded as a sign of a pathological susceptibility to infection by a worm (helminth)." [PMID:18382743]	—	HP:0032101
HPO	HP:0020108	Unusual parasitic infection	"An unusual parasitic infection that is regarded as a sign of a pathological susceptibility to infection by a parasite." [PMID:16148530]	—	HP:0032101
HPO	HP:0020110	Bone fracture	"A partial or complete breakage of the continuity of a bone." []	—	HP:0011842
HPO	HP:0020111	Abnormal CD4+CD25+ regulatory T cell proportion	"A deviation from the normal proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells." [PMID:19751267]	Identification of Treg cells remains problematic, because accumulating evidence suggests that all the presently-used Treg markers (CD25, CTLA-4, GITR, LAG-3, CD127 and Foxp3) represent general T-cell activation markers, rather than being truly Treg-specific.	HP:0025540
HPO	HP:0020112	Increased proportion of CD4+CD25+ regulatory T cells	"An abnormally increased proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells." []	—	HP:0020111
HPO	HP:0020113	Decreased proportion of CD4+CD25+ regulatory T cells	"An abnormally decreased proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells." []	—	HP:0020111
HPO	HP:0020114	Persistent human papillomavirus infection	"Human papillomaviruses (HPVs) are small oncogenic viruses. HPV has been shown to cause a variety of lesions and malignancies, which predominantly affect the anogenital region. Low-risk, non-oncogenic HPV types are associated with anogenital warts and recurrent respiratory papillomatosis while high-risk, oncogenic types are associated with cervical, penile, anal, vaginal, vulvar, and oropharyngeal cancers. Infection with anogenital HPV is usually asymptomatic and resolves spontaneously without consequences in the immunocompetent host. When disease does occur, the most common manifestation is genital warts, which may be small papules, or flat, smooth or pedunculated lesions. This resolution of HPV lesions is not generally seen in the immunosuppressed, resulting in severe, persistent and extensive manifestations of HPV disease." [PMID:24643184, PMID:26239127]	—	HP:0032169
HPO	HP:0020117	Hypoplastic dermoepidermal hemidesmosomes	"Underdeveloped hemidesmosomes at the dermoepidermal junction. Hemidesmosomes are the specialized junctional complexes, that contribute to the attachment of epithelial cells to the underlying basement membrane in stratified and other complex epithelia, such as the skin." [PMID:11851880, PMID:25487405]	With this feature, the intracellular attachment plates may be thinner than usualler or separated into small, triangular segments. The thickness of the hemidesmosomes may be less than usual.	HP:0032449
HPO	HP:0020118	Radial artery aplasia	"Congenital absence of the radial artery." [PMID:24650137]	—	HP:0031640
HPO	HP:0020119	Abnormal retinal nerve fiber layer morphology	"A structural abnormality of the retinal nerve fiber layer" []	The retinal nerve fiber layer consists of unmyelinated ganglion cell axons coursing on the vitreal surface of the retina to the optic disk. These axons become myelinated after entering the optic nerve.	HP:0000479