| HPO |
HP:0012649 |
Increased inflammatory response |
"A abnormal increase in the inflammatory response to injury or infection." [MONARCH:mhaendel] |
— |
HP:0012647 |
| HPO |
HP:0012650 |
Perisylvian polymicrogyria |
"Polymicrogyria (an excessive number of small gyri or convolutions) that is maximal in perisylvian regions (the regions that surround the Sylvian fissures), which may be symmetric or asymmetric and may extend beyond perisylvian regions. The Sylvian fissures often extend posteriorly and superiorly." [COST:neuromig, HPO:probinson, PMID:15159468, PMID:20301504] |
The Sylvian fissure (also known as the lateral sulcus) separates the frontal and parietal lobes superiorly from the temporal lobe inferiorly. |
HP:0002126 |
| HPO |
HP:0012651 |
Abasia |
"A severe form of gait ataxia such that an affected person cannot walk at all." [HPO:probinson] |
— |
HP:0002066 |
| HPO |
HP:0012652 |
Exercise-induced asthma |
"Asthma attacks following exercise." [HPO:probinson] |
— |
HP:0002099 |
| HPO |
HP:0012653 |
Status asthmaticus |
"Severe asthma unresponsive to repeated courses of beta-agonist therapy such as inhaled albuterol, levalbuterol, or subcutaneous epinephrine." [HPO:probinson, PMID:22794687] |
— |
HP:0002099 |
| HPO |
HP:0012654 |
Abnormal CSF dopamine level |
"Abnormal concentration of dopamine in the cerebrospinal fluid (CSF)." [Monarch:mhaendel] |
— |
HP:0025454 |
| HPO |
HP:0012655 |
Elevated CSF dopamine level |
"Increased concentration of dopamine in the cerebrospinal fluid (CSF)." [Monarch:mhaendel] |
— |
HP:0012654 |
| HPO |
HP:0012656 |
Reduced CSF dopamine level |
"Decreased concentration of dopamine in the cerebrospinal fluid (CSF)." [Monarch:mhaendel] |
— |
HP:0012654 |
| HPO |
HP:0012657 |
Abnormal brain positron emission tomography |
"A functional brain anomaly detectable by positron emission tomography (PET). PET scanning is a method for functional brain imaging, and its measurements reflect the amount of brain activity in the various regions of the brain." [HPO:probinson] |
Note that while structural brain anomalies can cause abnormal brain PET scan results, structural abnormalities are detectable by multiple neuroimaging modalities and should be coded using terms from the hierarchy under 'Abnormality of nervous system morphology' (HP:0012639). |
HP:0410263 |
| HPO |
HP:0012658 |
Abnormal brain FDG positron emission tomography |
"An anomaly detectable in [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) brain scans. Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity." [HPO:probinson] |
— |
HP:0012657 |
| HPO |
HP:0012659 |
Prefrontal hypometabolism in FDG PET |
"Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the prefrontal cortex as measured by positron emission tomography (PET) brain scan." [HPO:probinson, PMID:23585882] |
Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity, thus this sign indicates reduced metabolic activity in the prefrontal cortex. |
HP:0012658 |
| HPO |
HP:0012660 |
Thalamic hypometabolism in FDG PET |
"Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the thalamus as measured by positron emission tomography (PET) brain scan." [HPO:probinson] |
Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity, thus this sign indicates reduced metabolic activity in the thalamus. |
HP:0012658 |
| HPO |
HP:0012661 |
Hypothalamic hypometabolism in FDG PET |
"Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the hypothalamus as measured by positron emission tomography (PET) brain scan." [HPO:probinson] |
Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity, thus this sign indicates reduced metabolic activity in the hypothalamus. |
HP:0012658 |
| HPO |
HP:0012662 |
Parietal hypometabolism in FDG PET |
"Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the parietal cortex as measured by positron emission tomography (PET) brain scan." [HPO:probinson, PMID:15073255] |
Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity, thus this sign indicates reduced metabolic activity in the parietal cortex. |
HP:0012658 |
| HPO |
HP:0012663 |
Mildly reduced ejection fraction |
"A small reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at least 50 percent, and a mild reduction is defined as 40-49 percent." [HPO:probinson, PMID:16376782, PMID:27206819] |
— |
HP:0012664 |
| HPO |
HP:0012664 |
Reduced ejection fraction |
"A diminution of the volumetric fraction of blood pumped out of the ventricle with each cardiac cycle." [HPO:probinson] |
The normal range is at least 55 percent. |
HP:0003116, HP:0025169 |
| HPO |
HP:0012665 |
Moderately reduced ejection fraction |
"A medium reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle." [HPO:probinson, PMID:16376782, PMID:27206819] |
The normal range in adults is over 50 percent, and a moderate reduction can be defined as 30-39 percent. |
HP:0012664 |
| HPO |
HP:0012666 |
Severely reduced ejection fraction |
"A large reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at over 50 percent, and a severe reduction is defined as less than 30 percent." [HPO:probinson, PMID:16376782, PMID:27206819] |
— |
HP:0012664 |
| HPO |
HP:0012667 |
Regional left ventricular wall motion abnormality |
"An abnormal motion of a segment of the left ventricle during the cardiac cycle." [HPO:probinson] |
This feature can be appreciated using color kinesis, which tracks the motion of the endocardium in real time throughout systole and results in color-encoded images reflecting the magnitude and timing of endocardial motion. |
HP:0003116 |
| HPO |
HP:0012668 |
Vasovagal syncope |
— |
— |
HP:0001279 |
| HPO |
HP:0012669 |
Carotid sinus syncope |
"An exaggerated response to carotid sinus baroreceptor stimulation resulting in syncope from transient diminished cerebral perfusion." [HPO:probinson] |
Carotid sinus syncope cam be elicited mechanical manipulation of the carotid sinuses (eg, taking pulses in the neck, shaving). |
HP:0001279 |
| HPO |
HP:0012670 |
Orthostatic syncope |
"Syncope following a quick change in position from lying down to standing." [HPO:probinson] |
— |
HP:0001279 |
| HPO |
HP:0012671 |
Abulia |
"Poverty of behavior and speech output, lack of initiative, loss of emotional responses, psychomotor slowing, and prolonged speech latency." [HPO:probinson, PMID:16030444, UToronto:HTrang] |
Abulia is less severe thana kinetic mutism, and more so than apathy. |
HP:0000745 |
| HPO |
HP:0012672 |
Akinetic mutism |
"Akinetic mutism is essentially characterized by a total absence of spontaneous behavior and speech occurring in the presence of preserved visual tracking." [HPO:probinson] |
— |
HP:0000745 |
| HPO |
HP:0012673 |
Aplasia of the upper vagina |
"A failure to develop of the upper vagina." [HPO:probinson] |
The female reproductive tract primarily develops from the Mullerian ducts (MD), which form as an invagination of the coelomic epithelium and further develop into the upper two-thirds of the vagina, the uterus and the Fallopian tubes. Complete aplasia of the uterus, cervix, and upper vagina is termed Mullerian aplasia. This term refers to the aplasia of the upper roughly two thirds of the vagina that is characteristic of Mullerian aplasia. |
HP:0003250 |