| HPO |
HP:0000727 |
Frontal lobe dementia |
— |
— |
HP:0000726 |
| HPO |
HP:0000728 |
Impaired ability to form peer relationships |
— |
— |
HP:0000735 |
| HPO |
HP:0000729 |
Autistic behavior |
"Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior." [HPO:probinson, PMID:28879490] |
This term can be used to refer to autism spectrum disorder as a phenotypic feature that can be a component of a disease. Autism spectrum disorder range from a severe form, called autistic disorder, to a milder form, Asperger syndrome. |
HP:0000708 |
| HPO |
HP:0000732 |
Inflexible adherence to routines or rituals |
— |
— |
HP:0000708 |
| HPO |
HP:0000733 |
Stereotypy |
"A stereotypy is a repetitive, simple movement that can be voluntarily suppressed. Stereotypies are typically simple back-and-forth movements such as waving of flapping the hands or arms, and they do not involve complex sequences or movement fragments. Movement is often but not always rhythmic and may involve fingers, wrists, or more proximal portions of the upper extremity. The lower extremity is not typically involved. Stereotypies are more commonly bilateral than unilateral." [HPO:probinson] |
An abnormality of behavior characterized by one or more stereotyped and restricted patterns of behavior such as inflexible adherence to specific, nonfunctional routines or rituals, stereotyped and repetitive motor mannerisms (e.g., hand or finger flapping or twisting, or complex whole-body movements), or persistent preoccupation with parts of objects. The behaviour does not serve an observable goal. In general the movements are not aimed at the environment, but at the person itself. Stereotypical behaviour is seen especially in children with sensory, intellectual and/or cognitive handicaps. |
HP:0004305 |
| HPO |
HP:0000734 |
Disinhibition |
"A lack of restraint manifested in several ways, including disregard for social conventions, impulsivity, and poor risk assessment." [HPO:sdoelken] |
Disinhibition affects motor, instinctual, emotional, cognitive and perceptual aspects with signs and symptoms similar to the diagnostic criteria for mania. Hypersexuality, hyperphagia, and aggressive outbursts are indicative of disinhibited instinctual drives. |
HP:0031466 |
| HPO |
HP:0000735 |
Impaired social interactions |
"Difficulty in social interactions related to an impairment of characteristics such as eye contact, smiling, appropriate facial expressions, and body postures and characterized by difficulty in forming peer relationships and forming friendships." [HPO:probinson] |
— |
HP:0000729, HP:0012433 |
| HPO |
HP:0000736 |
Short attention span |
"Reduced attention span characterized by distractibility and impulsivity but not necessarily satisfying the diagnostic criteria for attention deficit hyperactivity disorder." [HPO:curators] |
— |
HP:0000708 |
| HPO |
HP:0000737 |
Irritability |
"A proneness to anger, i.e., a condition of being easily bothered or annoyed." [PMID:27343883] |
— |
HP:0100851 |
| HPO |
HP:0000738 |
Hallucinations |
"Perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space." [HPO:sdoelken] |
— |
HP:0000708 |
| HPO |
HP:0000739 |
Anxiety |
"Intense feelings of nervousness, tenseness, or panic, often in reaction to interpersonal stresses; worry about the negative effects of past unpleasant experiences and future negative possibilities; feeling fearful, apprehensive, or threatened by uncertainty; fears of falling apart or losing control." [HPO:probinson, PMID:23902698] |
— |
HP:0100852 |
| HPO |
HP:0000740 |
Episodic paroxysmal anxiety |
"Recurrent attacks of severe anxiety, whose occurence is not restricted to any particular situation or set of circumstances and is therefore unpredictable." [] |
An anxiety attack may manifest with one or more of the following symptoms: (i) breathing difficulty; (ii) palpitations; (iii) a feeling of unreality; (iv) pains or tightness in the chest; (v) trembling, dizziness or feeling unsteady; (vi) sweating; (vii) a feeling of faintness; (viii) a fear of dying; (ix) a feeling of losing control; (x) tingling in hands and feet (parasthesiae); (xi) choking or smothering feelings. |
HP:0000739 |
| HPO |
HP:0000741 |
Apathy |
— |
— |
HP:0000745 |
| HPO |
HP:0000742 |
Self-mutilation |
— |
— |
HP:0100716 |
| HPO |
HP:0000743 |
Frontal release signs |
"Primitive reflexes traditionally held to be a sign of disorders that affect the frontal lobes." [HPO:sdoelken] |
— |
HP:0100022 |
| HPO |
HP:0000744 |
Low frustration tolerance |
"The feeling of frustration can be defined as an emotional reaction that occurs if a desired goal is not achieved. Frustration intolerance is defined as an age-inappropriate response to frustration characterized by crying or temper tantrums (in children) or aggressive or other undesirable behaviors." [PMID:21461367] |
— |
HP:0100851 |
| HPO |
HP:0000745 |
Diminished motivation |
"A reduction in goal-directed behavior, that is, motivation, the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action." [HPO:probinson, PMID:16030444] |
— |
HP:0100851 |
| HPO |
HP:0000746 |
Delusions |
"A false belief that is held despite evidence to the contrary." [HPO:sdoelken] |
— |
HP:0000708 |
| HPO |
HP:0000748 |
Inappropriate laughter |
— |
— |
HP:0000719 |
| HPO |
HP:0000749 |
Paroxysmal bursts of laughter |
— |
— |
HP:0000748 |
| HPO |
HP:0000750 |
Delayed speech and language development |
"A degree of language development that is significantly below the norm for a child of a specified age." [HPO:probinson] |
Language delay can be characterized by a failure to meet the developmental milestones for language development, an inability to follow directions, or slow or incomprehensible speech after the age of three years, as well as with severe problems with syntax or articulation. |
HP:0002167, HP:0002463, HP:0012758 |
| HPO |
HP:0000751 |
Personality changes |
"An abnormal shift in patterns of thinking, acting, or feeling." [HPO:probinson] |
This term refers to changes in personality that are perceived as being abnormal. It does not refer to the usual gradual personality changes that tend to accompany aging and certain life situations. |
HP:0000708 |
| HPO |
HP:0000752 |
Hyperactivity |
"Hyperactivity is a state of constantly being unusually or abnormally active, including in situations in which it is not appropriate." [ORCID:0000-0002-6713-2943] |
— |
HP:0000708 |
| HPO |
HP:0000753 |
Autism with high cognitive abilities |
— |
— |
HP:0000729 |
| HPO |
HP:0000756 |
Agoraphobia |
"A type of anxiety disorder characterized by avoidance of public places, especially where crowds gather." [HPO:probinson] |
— |
HP:0100852 |